【摘要】 目的比较吸烟未患慢性阻塞性肺疾病(COPD)者和吸烟患COPD者血清中性粒细胞弹性蛋白酶(NE)和α1-抗胰蛋白酶(α1-AT)含量有无明显差别,进而明确检测血清酶学有无早期诊断COPD的意义。方法入选33例吸烟伴COPD的稳定期住院患者、33例吸烟不伴COPD的健康体检者及20例健康对照者,检测三组对象的血清NE和α1-AT的含量。结果血清中NE含量,在吸烟伴COPD者为55.21 ng/mL,明显高于吸烟不伴COPD者(25.76 ng/mL),P值均<0.01;血清中α1-AT含量:吸烟伴COPD者与不伴COPD者比较差异无统计学意义(P>0.05)。结论检测血清中NE含量有早期诊断COPD的意义。更多还原

【Abstract】 Objective To compare the difference of neutrophil elastase(NE) and α1-antitrypsin(α1-AT) between the smokers with or without COPD and to investigate whether NE and α1-AT can be used for COPD early diagnosis.Methods A total of 33 smokers with stable phase COPD,33 smokers without COPD and 20 normal people were enrolled in the study.The serum levels of NE and α1-AT were detected by ELISA.Results There was a significant increase of NE in the smokers with COPD compared to those without COPD(55.21 ng/mL vs 25.76 ng/mL,P < 0.01).However,there was no changes of α1-AT between the smokers with or without COPD(P > 0.05).Conclusion NE may be used for the early diagnosis of COPD.更多还原