Objective To study daphnane diterpene esters from the flower buds of Daphne genkwa and to evaluate their cytotoxicity against tumor cells.Methods The compounds were isolated and purified by means of chromatographic techniques and their structures were identified on the basis of spectral features.Cytotoxic activity against NCI-H1975 lung cancer cells and SK-BR-3 breast cancer cells were assessed for all the compounds by MTT method.Results Six compounds were isolated and identified as isoyuanhuacin(1),yuanhua...