【摘要】 目的探讨兰菌净疫苗对儿童呼吸道反复感染的预防效果。方法采用随机、双盲、对照的方法。收集深圳市上梅林社区6月龄～1 2周岁符合反复呼吸道感染诊断标准的儿童1 0 8例,随机分为疫苗组与对照组(每组54例),在双盲背景下给予兰菌净或安慰剂。随访观察1 2个月,滴服前后8周取空腹静脉血进行血常规、肾功能及血清IgA、T细胞亚群、免疫球蛋白测定。服疫苗前、后第1、2、3、6、9和1 2月留取唾液及血清进行sIgA测定。所有数据采用S P S S 20.0统计软件包进行统计学处理。结果与对照组相比,疫苗组患儿干预后呼吸道感染次数、发热天数、咳嗽天数和咽痛天数均显著减少,差异具有统计学意义(P<0.0 5或0.0 1)。干预第1、3、6个月后唾液sIgA与干预前比较均有显著升高,第6个月到达峰值,以后慢慢减少,到第1 2月时与干预前水平基本等同;干预3个月后血清IgA与干预前比较也有显著升高。与对照组比较也显示显著升高,对照组干预前后差异无统计学意义(P>0.0 5)。干预后,疫苗组CD 3、CD 4、IgG、IgA明显高于对照组(P<0.0 1)。结论兰菌净对儿童反复呼吸道感染的预防效果安全而明显,值得推广与应用。更多还原

【Abstract】 Objective To investigate the preventive-effect of Lantigen B for the children with recurrent respiratory infections.Method We use random,double blind and comparing ways to collected data of 108 childred age from six months to twelve years old in Shenzhen Shangmeilin community.They were divided into two groups,one of them received Lantigen B and one of them received placebo.Followed up for 12 months,before the test start and after the test started for 8 weeks,we take the venous blood to do the routine blood test.Renal function tests,IgA,T-cell and determination of immunoglobulin.Before and after the test of inoculation for 1,2,3,6,9 and 12 months,we took the spit and blood to do the SIgA-test.For all the datas,we use SPSS20.0 to do the statistical analysis.Results Compared with the control group,there were significant reduction among the the number of respiratory tract infection,days of fever,cough days and sore throat stay after intervention;these differences were all statistically significant(P<0.05 or 0.01).The spit sIgA concentration increased significantly after treatment with Lantigen B,in from 1 to 6 months of observation period than the test before,and it reach peak in 6th months,it reduced slowly from now,till the 12th months it was the sme as before the intervention level.The blood IgA concentration increased significantly after treatment with Lantigen B for 3 months.Compared with the control group it increased significantly.However,the control group had no obvious change before and after the intervention(P>0.05).Vaccine group was significantly higher than that of the control group among CD3、CD4、IgG、IgA(P<0.01)after intervene.Conclusion The preventive-effect of Lantigen B was safety and obvious,it worth to being extension.更多还原