【摘要】 目的探讨心理干预结合小剂量抗抑郁药物治疗消化性溃疡的临床疗效。方法以我院2006年6月至2012年10月收治的148例消化性溃疡患者作为研究对象。随机分为对照组(74例)和治疗组(74例)。对照组采用单纯常规药物治疗,治疗组在常规药物治疗基础上结合心理干预和小剂量抗抑郁药物治疗。分别观察两组患者在疗效上的差异情况。结果所有患者在治疗2个月后进行复查。治疗组治愈57例,有效14例,无效3例,总有效率95.9%;对照组治愈47例,有效17例,无效10例,总有效率86.5%;两组在治愈率和总体有效率上比较差异有统计学意义(P<0.05)。治疗后6个月后随访,治疗组复发率(7.0%)低于对照组(14.9%)(P<0.05)。结论消化性溃疡患者常存在焦虑抑郁心理问题,在积极进行常规内科治疗的同时,结合心理干预和小剂量抗抑郁药物治疗,能更好地提高疗效,促进溃疡的愈合。更多还原

【Abstract】 Objective To investigates the clinical effects of combination of psychological and small doses of antidepressant on patients with peptic ulcer. Methods 148 patients with peptic ulcer, who treated in our hospital from June 2006 t o October 2012, were divided into two groups randomly. The control group was treated only by conventional medicaments; the treatment group was treated by conventional medicaments in combination with psychological and small doses of antidepressant. Results After 2 months of treatment, there were 57 patients were cured and 14 cases improved in treatment group, and the total effective rate was 95.9%. In control group, there were 47 patients were cured and 17 cases improved, and the total effective rate was 86.5%. The statistically significant difference was detected between the two groups in terms of cure rate and total effective rate(P<0.05). The follow-up after 6 months of treatment showed that the recurrence rate of treatment group was lower than that of in control group(P<0.05). Conclusion Many patients with peptic ulcer usually have psychological problems such as anxiety and depression. Treatment of conventional medicaments in combination with psychological and small doses of antidepressant could improve the clinical effect and the healing of peptic ulcer.更多还原