【摘要】 目的探讨包皮环切术对男性高危型HPV感染的预防作用。方法收集我院2001年6月至2010年6月十年间普外门诊行包皮环切术的患者临床资料276例,另取我院体检中心体检的包皮过长而未行包皮环切术的健康男性276例作为对照。HPV-DNA分型基因芯片检测高危型HPV病毒的表达。结果 552例受试者中共检测到高危型HPV感染157例,感染率为28.4%。治疗前治疗组感染80例,感染率为29.0%;对照组感染77例,感染率为27.9%,两组之间无显著性差异(P>0.05)。包皮环切术后2年,治疗组高危型HPV感染率从29.0%减少到11.9%,二者之间具有显著性差异(P<0.05)。对照组为29.3%,与治疗前无显著性改变(P>0.05)。结论包皮环切术可以预防男性高危型HPV的感染,值得积极推广应用。更多还原

【Abstract】 Objective To investigate the clinical effects of circumcision on infection of high-risk human papilloma virus(HPV) in adult males.Methods A total of 276 adult males with circumcision were collected and analyzed in our hospital.Another 276 phimosis without circumcision were recruited in the control group.The high-risk HPV was detected by HPV-DNA genotyping chip.Results 157 cases were infected by high-risk HPV in 552 phimosis,and the infection rate was 28.4%.Before circumcision,80 cases were infected by high-risk HPV with an infection rate of 29.0% in treatment group,and 77 cases were infected by high-risk HPV with an infection rate of 27.9% in control group.There was no significant difference between the two groups(P>0.05).After circumcision,the infection rate of high-risk HPV was significantly decreased from 29.0% to 11.9% in treatment group(P<0.05).However,the infection rate of high-risk HPV was 29.3% in control group and no significant difference was found cmparing with two years ago(P>0.05).Conclusion Circumcision can effectively reduce high-risk HPV infection,and which was worthy to promote the clinical application.更多还原