【摘要】 目的研究伽玛刀治疗原发性三叉神经痛的疗效,评价治疗剂量与疗效的关系。方法对2002年7月至2010年8月间124例患者进行伽玛刀治疗。选择靶点为三叉神经根近端,伽玛刀治疗处方剂量为70～90Gy。根据不同的照射剂量随机分为<80 Gy和>80 Gy两组。治疗后定期随访,进行疗效分析。结果随访124例,随访21～69个月(平均32个月)。疼痛完全消失62例(50%),疼痛基本消失31例(25%),疼痛缓解23例(18.5%),无效8例(6.5%),有效率93.5%。治疗中心剂量<80 Gy和>80 Gy两组在显效率方面没有显著差异(P>0.01)。结论伽玛刀治疗原发性三叉神经痛安全有效,治疗剂量考虑75～80Gy为最佳。更多还原

【Abstract】 Objective To Study and evaluate the effects of Gamma knife to treat ingprimary trigeminal neuralgia.Methods Between July 2002 and August 2010,124 patients with primary trigeminal neuralgia were treated with Gamma Knife.the chosen target was the root of trigeminal nerve just anterior to pons,The prescribed doses of the treatments were 70~90Gy.The patients were randomly divided into tow groups(<80 Gy和>80 Gy).After treatment,the patient were followed up for long time.Results 124 patients were followed up for 21 to 69 months with mean term of 32 months.The pain completely disappeared in 62 cases(50%),The pain basically disappeared in 31 cases(25%),the pain relief occurred in 23 cases(18.5%),and in 8 patient(6.5%) the pain was unchanged,efficiency 93.5%.There wasn’t significant difference in pain relief between the tow groups(P>0.01).Conclusion Treatment of primary trigeminal neuralgia with Gamma knife is effective and safe methods.75~80Gy radiation dose should be as most suitable.更多还原