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正交设计优选健脾颗粒中橙皮苷的提取工艺

Optimization of Extraction Technology of Hesperidin in Jianpi Granules Using Orthogonal Design

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【作者】 林清符小英马晓鹂

【Author】 LIN Qing1,FU Xiao-ying2,MA Xiao-li1((1.Dept.of Pharmacy,The Affiliated Hospital of Guangdong Medical College,Guangdong Zhanjiang 524001,China;2.Guangdong Hengcheng Pharmaceutical Co.Ltd.,Guangdong Zhanjiang 524022,China)

【机构】 广东医学院附属医院药学部广东恒诚制药有限公司

【摘要】 目的:优选健脾颗粒中橙皮苷的提取工艺。方法:以处方中的主要药效成分橙皮苷含量为观察指标,采用正交设计法筛选最佳提取工艺条件。结果:最佳提取方法为回流1.0 h、加95%甲醇50 ml。结论:优选的提取方法为健脾颗粒中橙皮苷含量测定提供可靠方案,保证产品质量。

【Abstract】 OBJECTIVE:To optimize the extraction technology of hesperidin in Jianpi granules(granules for strengthening spleen).METHODS:The extraction technology of hesperidin in Jianpi granulea was optimized using orthogonal design with the main active component hesperidin as observation index.RESULTS:The optimal extracting technology for hesperidin were as follows:95% methanol(50 ml) were added for refluxing of 1 hour.CONCLUSION:The optimized extraction technology serves as a reliable scheme for determination of the content of hesperidin in Jianpi granules and thus ensuring the quality of Jianpi granules.

【关键词】 正交设计橙皮苷提取工艺
【Key words】 Orthogonal designHesperidinExtraction technology
  • 【文献出处】 中国医院用药评价与分析 ,Evaluation and Analysis of Drug-Use in Hospitals of China , 编辑部邮箱 ,2013年05期
  • 【分类号】TQ461;R286.0
  • 【被引频次】4
  • 【下载频次】112
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