【摘要】 目的分析可能影响戒烟效果的因素,为戒烟患者提供更有效更科学的干预措施。方法以问卷形式记录门诊戒烟患者的基本资料,并给予药物等综合干预措施,随后对就诊的戒烟患者分时间段定期随防48周,汇总并分析可能影响戒烟效果的因素。结果首诊满12,24,48周可随访患者的总体成功戒烟率分别为35.9%,33.3%和31.0%;在满12和24周时使用伐尼克兰比未使用药物的戒烟成功率高(P<0.01),但在48周时差异无统计学意义;有戒烟经历的患者在满12和24周时的戒烟成功率显著高于无戒烟经历的患者(P<0.01),未发现其他因素影响戒烟成功率;在所有的患者中,12周戒烟效果与24和48周的戒烟效果高度一致(P<0.01)。结论曾有过戒烟经历的患者可能更容易戒烟成功;前12周为戒烟能否成功的关键时期,使用伐尼克兰则可能有助于成功戒烟。更多还原

【Abstract】 Objective To explore the effect of the relevant factors and different interventions on tobacco cessation and provide evidence-based strategies for smoking intervention.Methods Questionnaires were collected to record the basic information of patients who agreed to quit smoking,and comprehensive interventions as giving smoking cessation drugs were performed.Then the patients were followed for 48 weeks by telephone regularly.The different interventions for the successful smoking cessation programs were collected and analyzed.Results The total percentage of patients who remained tobacco-free clinic after 12,24 and 48 weeks was 35.9%,33.3%,and 31.0%,respectively.The success rate was significantly higher in patients treated with varenicline benefits than those without treatment after 12 and 24 weeks(P<0.01).However,there was no statistical difference in quitting smoking after 48 weeks.Patients who were previously enrolled in the smoking cessation programs had higher success rate 12 and 24 weeks later,as compared to first-time quitters.(P<0.01).Patients who left the clinic 12 weeks after treatment has very similar success rate as compared to those who left the clinic 24 and 48 weeks later(P<0.01).Conclusion Patients who have previous attempts of tobacco cessation supposed to be easier to quit smoking.The first 12 weeks is the most critical period for smoking cessation and varenicline may provide additional benefits.更多还原