【摘要】 胰岛素的基础分泌是指其少量持续的分泌。常规人胰岛素由于不能很好地在糖尿病患者中重建正常生理性胰岛素分泌,低血糖发生率较高,影响了其临床应用。随着基因工程技术的发展,一批新出现的长效胰岛素类似物可以模拟正常人胰岛素的基础分泌,在注射后持续少量的释放。而目前3种新型的长效胰岛素类似物:甘精胰岛素、地特胰岛素和德谷胰岛素,虽然都通过改变胰岛素的等电点或增加类似物分子量的方法,使其分解、吸收及作用时间延长,更好地模拟正常人胰岛素的基础分泌,但其在分子结构、长效机制、生产工艺和临床使用上又有诸多不同。更多还原

【Abstract】 The basal secretion of insulin is continuous low secretion.Regular human insulin secretion,the normal physiological insulin in diabetic patients can’t rebuild a higher incidence of hypoglycemia,its clinical application. With the development of genetic engineering technology,the long-acting insulin analogues can simulate normal human insulin secretion after the injection for a small amount of release.Insulin glargine,detemir and degludec are all of human insulin analogs produced,although they are by changing the isoelectric point of insulin or increasing analogs molecular weight,to break down and absorption and extend the duration of action and simulate normal human insulin secretion,but having different molecular structure,long acting mechanisms,artworks and different clinical effects.更多还原