【摘要】 目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并充血性心力衰竭(congestive heart failure,CHF)患者B型钠尿肽(B-type natriuretic peptide,BNP)水平的变化及临床意义。方法:选取慢性阻塞性肺疾病急性加重期(acute exacerbation chronic obstructive pulmonary disease,AECOPD)患者(59例)作为A组,COPD合并CHF患者(63例)作为B组;另选取健康体检正常者(30例)作为C组。采用免疫荧光快速测试法测定受试者血浆BNP水平并分析。结果:血浆BNP水平B组显著高于A组和C组(P<0.01);而A组显著高于C组(P<0.01)。B组患者治疗后血浆BNP水平明显下降(P<0.01),治疗后血浆BNP水平B组略高于A组但无显著性差异(P>0.05)。结论:COPD合并CHF时BNP水平明显升高,提示BNP测定对鉴别COPD合并CHF有一定意义,同时可作为COPD合并CHF患者治疗效果的评价指标。更多还原

【Abstract】 Objective:To explore the changes and clinical significance of B-type natriuretic peptide(BNP)in patients with chronic obstructive pulmonary disease(COPD)and congestive heart failure(CHF).Methods:There were 59 patients with the AECOPD,63 COPD patients with CHF,and 30 healthy people;from which BNP were analysed.Results:The levels of BNP in COPD patients with CHF were significantly higher than AECOPD group and healthy control group(P<0.01);AECOPD group higher than healthy control group(P<0.01).The levels of BNP in COPD patients with CHF were significantly decreased after treatment(P<0.01).The levels of BNP in COPD patients with CHF and AECOPD group were no different after treatment(P>0.05).Conclusion: The levels of BNP in COPD patients with CHF are increased,BNP to identify CHF and COPD have significance,and can be used as the judgment of the treatment effect of CHF.更多还原