【摘要】 妊娠是一个复杂而又协调的生理过程,母-胎界面正常免疫耐受的建立和维持是妊娠成功与否的关键。母体胎盘、激素水平、黏附分子、细胞因子、人类白细胞抗原、自然杀伤细胞、调节性T淋巴细胞等在母-胎免疫耐受过程中均有重要作用。此外,吲哚胺2,3-双加氧酶作为一种分解代谢酶,其自身的表达调控及其与多种免疫因子、免疫细胞的相互作用在妊娠免疫耐受中也发挥着重要而复杂的作用。更多还原

【Abstract】 Pregnancy is a complex and harmonious physiological process. The establishment and maintenance of maternal-fetal immunological tolerance is critical for normal pregnancy. The maternal placenta,level of hormones,adhesion molecule,cytokines,human leukocyte antigen,natural killer cell and regulatory T cell play important roles in maternal-fetal immunological tolerance. Additionally,the indoleamine 2,3-dioxygenase,a catabolic enzyme,exerts vital and complex effects on maternal-fetal tolerance by regulating its selfexpression and interactions with a variety of immune molecules and cells.更多还原