【摘要】 梅尼埃病是以膜迷路积水为主要病理改变,以发作性眩晕、耳聋、耳鸣和耳胀满感为临床特征的常见的特发性内耳慢性疾病,病因不明。近几年梅尼埃病的基因学研究越来越受到关注。该文就梅尼埃病相关基因,包括报道较多的人类白细胞抗原、水通道蛋白、群体凝血因子C同源物基因以及最近较为热门的白细胞介素1基因、热休克蛋白70基因以及钾离子通道基因的研究新进展予以综述。更多还原

【Abstract】 Ménière’s Disease(MD) is a chronic disorder affecting the inner ear characterized by recurrent episodes of spontaneous vertigo,sensorineural hearing loss,aural pressure and tinnitus,however the etiology is unknown.Its main pathological change is inner ear water.In recent years more and more attention are paid in the genetic research of Ménière’s Disease.Here is to make a review of the recent research progress of genetics(human leucocyte antigen,aquaporins,coagulation factor C homology,interleukin-1,heat shock protein 70,KCNE) of Ménière’s Disease.更多还原