【摘要】 RNA干扰(RNAi)是外源和内源性双链RNA在生物体内诱导同源靶基因的mRNA特异性降解,导致转录后基因沉默的现象。RNAi过程分为三个阶段,即起始阶段、效应阶段及扩增阶段。RNAi是一种高效特异性的阻断基因表达的基因阻断技术,不仅在生物学功能方面起到作用,如病毒防御,抑制转座子的转座,保护基因组的稳定性,以及调节基因表达,在医学领域也有着广泛的应用,包括高血压、心肌病变、心力衰竭及脑血管疾病等。更多还原

【Abstract】 RNA interference( RNAi) is a phenomenon that specially degrades the corresponding sequence mRNA by the mediate of exogenous and endogenous double-stranded RNA( dsRNA) to induce the post-transcriptional gene silencing. The RNAi process is divided into three stages,namely initial stage,effecting stages and amplification stage. It is an efficient genetic interference technology not only in the biological function such as virus prevention,suppression of transposition,protection of genomic stability,and regulation of gene expression,but also in the medical domain. Here is to make a review of the research progress of its applications in hypertension,cardiomyopathy,heart failure and cerebrovascular disease.更多还原