【摘要】 由于当前缺乏早期筛查出遗传性弥漫型胃癌(HDGC)的有效方法,预防性全胃切除术(PTG)作为一种预防与治疗HDGC的特殊方法得以应用。PTG仅限于E钙黏蛋白基因胚系突变携带的HDGC家系成员。多学科会诊决定是否进行PTG。PTG切除范围包括齿线上1 cm食管、幽门下1 cm十二指肠,清扫第一站淋巴结,食管空肠Roux-Y型吻合术。术后可发生一般全胃切除术的并发症,无围术期死亡报告。多数患者被术后病理证实为印戒细胞癌。更多还原

【Abstract】 There is no good screening test currently for hereditary diffuse gastric cancer(HDGC) in early stage,so prophylactic total gastrectomy(PTG) is used as a special therapeutic and preventive method for HDGC.PTG has been limited to E-cadherin germline mutation-positive members from HDGC family.The final decision of PTG should be based on multidisciplinary consultation.The surgical procedure consists of a total gastrectomy with 1 cm esophagus above the squamocolumnar junction and 1 cm duodenum below the pyloric region.The D-1 lymphnode dissection and Roux-Y esophagojejunostomy is to be performed.The postoperative complications of general total gastrectomy may occur.There are no perioperative death reports.Pathological examination show that it’s multi foci signet ring cell carcinoma of stomach in the majority of cases.更多还原