【摘要】 偏头痛是一种临床较常见、慢性、反复发作的血管神经性头痛。偏头痛的发病机制目前尚未完全明确,病因也较为复杂,遗传、饮食、内分泌以及精神因素等均与偏头痛的发病有一定关系。偏头痛有明显的家族聚集性,但偏头痛的遗传方式尚不完全清楚,到目前为止,家族性偏瘫性偏头痛是唯一已知相关遗传学特征和致病基因的偏头痛,在家族性偏瘫性偏头痛中,目前已鉴定出三个致病基因位点。除家族性偏瘫性偏头痛基因外,偏头痛与5-羟色胺、一氧化氮合酶等基因也有一定相关性,但尚未得出一致性的结论。更多还原

【Abstract】 Migraine is a common,chronic recurrent angioneurotic headache in clinic.The pathogenesis of migraine is not yet fully understood,the cause is relatively complicated.Genetic,diet,endocrine and psychological factors are all correlated with the onset of migraine.Migraine shows obvious familial aggregation,though its genetic mode is not totally clear.So far,the Familial Hemiplegic Migraine(FHM) is the only migraine with known genetic characteristics and pathogenic gene,of which three pathogenic gene loci have been identified.Besides,recent studies found its related genes also include 5-hydroxytryptamine(5-HT),nitric oxide synthase(NOS) etc.,though unified conclusion has not been achieved yet.更多还原