【摘要】 Bcl-2、caspase-3、survivin是细胞凋亡过程中重要的调控基因,在银屑病角质形成细胞凋亡中,三种蛋白起着非常重要的作用。Bcl-2是一种凋亡抑制基因,可延长细胞的生存期,caspase-3可促进细胞凋亡,survivin是迄今发现最强的凋亡抑制因子,具有抑制细胞凋亡、促进细胞增殖的作用,在银屑病皮损中Bcl-2呈低表达,caspase-3、survivin呈高表达,三种蛋白的相互作用,可能导致银屑病角质形成细胞的生存期缩短、凋亡速度加快,同时细胞增殖明显,从而维持银屑病表皮的良性增生状态。更多还原

【Abstract】 Bcl-2,caspase-3,survivin genes are important genes in the process of apoptosis,playing important roles in psoriasis keratinocyte apoptosis.Bcl-2 is a kind of apoptosis suppressor gene,which can prolong life period of cells.Caspase-3 can promote cell apoptosis.Survivin is one of the strongest anti-apoptosis factor discovered so far,which can inhibit cell apoptosis and promote cell proliferation.Psoriasis lesions contain less Bcl-2,more caspase-3 and survivin.Interaction between them may result in the shortened life period and fastened apoptosis in psoriasis keratinocy,and cells proliferation is obvious,which maintains the benign proliferative state of psoriasis epidermis.更多还原