【摘要】 对超敏C反应蛋白(hs-CRP)、妊娠相关蛋白A(PAPP-A)及IVS6+95(C/G)基因多态性预测不稳定型心绞痛(UAP)患者经皮冠状动脉成形术(PCI)术后再狭窄的意义进行探讨。UAP患者行PCI术(TIMI血流达到3级),3个月～9个月复查冠脉造影,选取血管腔内径狭窄≥75%者(再狭窄组)86例、无再狭窄组(对照组)152例,测定术前术后24hPAPP-A、hs-CRP水平。采用基因测序法分析IVS6+95多态性。再狭窄组术后血清PAPP-A、hs-CRP水平较本组术前明显增高(P<0.001)。对照组术后血清PAPP-A、hs-CRP水平较本组术前明显下降(P<0.001)。再狭窄组IVS6+95中CC基因频率明显高于未发生组(P<0.05),而等位基因C频率无明显差异。PCI术后PAPP-A、hs-CRP血清水平可作为预测冠脉再狭窄的指标,IVS6+95(C/G)多态性可能与术后再狭窄有关,其中基因型CC是致病的基础。更多还原

【Abstract】 To explore the value of pregnancy associated plasma protein A,high sensitivity C-reactive protein and IVS6+95 gene polymorphism in prediction of restenosis after percutaneous coronary intervention.The patients with unstable angina pectoris were performed PCI.Those patients were classified as group A(86 cases with related coronary artery lumen loss more than 75% in diameter 3~9months after PCI) and group B(the rest 152 cases with related coronary lumen loss less than 75%).Serum PAPP-A and hs-CRP levels were examined before and 24h after coronary angiography.The gene polymorphisms was analyzed by gene sequencing.Serum PAPP-A and hs-CRP levels were significantly increased In group A and decreased in group B after PCI(P<0.001).The CC gene frequency of PAPP-A gene IVS6+95 was significantly higher in group A than in group B(P<0.05).But there were no difference in the frequency of allele C between two groups(P>0.05).PAPP-A and hs-CRP level increase after PCI have a strong power in prediction of coronary artery restenosis after PCI.The polymorphism of PAPP-A gene IVS6+95(C/G) may be associated with postoperative restenosis and CC genotypes may be the foundation of pathogen.更多还原