【摘要】 目的探讨保乳术在Ⅰ、Ⅱ期三阴性乳腺癌中的应用价值。方法回顾性分析2001年1月～2009年1月行保乳术治疗的108例乳腺癌患者的临床病理资料,三阴组40例,非三阴组68例,两组进行对比研究。同期收集行改良根治术的三阴性乳腺癌患者52例,与上述行保乳术的三阴性乳腺癌患者的预后进行对比研究。结果本组TNBC168例,占15.6%(168/1076),三阴组年龄≤40岁29例,占72.5%,肿瘤直径2～3cm者28例,占70%,以上指标与非三阴组比较,差异有统计学意义(P<0.05);所有患者随访3年,保乳术患者复发12例,转移6例,死亡8例,其中三阴组复发5例,转移3例,死亡6例,与非三阴组比较,复发率差异无统计学意义(P>0.05),远处转移率及3年生存率差异均有统计学意义(P<0.05);与改良根治组比较,复发率、远处转移率及3年生存率差异均无统计学意义(P>0.05)。结论 三阴性乳腺癌患者发病年龄较轻、肿瘤体积较大,行保乳术后复发率与非三阴组无差别,复发率、远处转移率及3年生存率与改良根治组均无差别,保乳术可以作为Ⅰ、Ⅱ期三阴性乳腺癌的手术选择。更多还原

【Abstract】 Objective To analyze and discuss the application value of breast conservation surgery in triple-negative breast cancer(TNBC) stageⅠand Ⅱ.Methods The clinical data of stageⅠandⅡbreast cancer patients underwent breast conservation surgery therapy(40 cases in triple-negative group and 68 sases in non-triple-negative group) and breast modified radical mastectomy therapy(modified radical mastectomy group 52 cases) in our hospital,during a period from Jan 2001 to Jan 2009,was retrospectively analyzed.Now we compared the prognosis between the breast conservation surgery group(triple-negative group)and the modified radical mastectomy group in this paper.Results Of the 1076 patients,15.6%(168/1076) was TNBC patients.In the TNBC patients,72.5% whose age was younger than forty years and 70% whose diameter was 2-3cm.The age and the tumor diameter were significantly greater in TNBC group than in non-TNBC group(P<0.05).The follow-up was 3 years.0f all the cases,12 occurred local recurrence,6 distant metastasis and 8 died.It was 5,3 and 6 in triple-negative(TN)group.Compared with the non-triple-negative(NTN)group,the TN cases were more likely to occurring distant metastasis(P<0.05).The 3-year survival rate in TN group were significantly higher than in NTN group(P<0.05).Compared with the modified radical mastectomy group,for the local recurrence rate,distant metastasis rate and 3-year survival rate,there were no significant differences(P>0.05).Conclusion These patients of TNBC were usually young(age<40),with tumor being large.There was no significant difference between TN and NTN in local recurrence rate,which under breast conservation surgery.There was no significant difference in local recurrence rate,distant metastasis rate and 3-year survival rate between the breast conservation group(TN) and the modified radical mastectomy group.So the breast conservation surgery treatment way is preferred for TNBC stageⅠ and Ⅱ.更多还原