【摘要】 目的:探讨急性胰腺炎患者血浆vWF因子和IL-6的变化及其临床意义。方法:应用ELISA法对重症急性胰腺炎组(24例)、轻型急性胰腺炎组(44例)及对照组(15例)血浆中的vWF因子和IL-6进行测定。结果:三组病例血浆中的vWF分别为(230.5±52.7)%、(175.8±30.3)%、(84.5±21.3)%;IL-6分别为(68.76±28.62)ng/ml、(35.95±11.56)ng/ml、(14.46±3.53)ng/ml,三组之间差异显著(P<0.05)。血浆vWF因子和IL-6预测重症AP的敏感性、特异性和准确性分别是96.7%、86.7%、91.6%和60%、90%、75%。结论:检测血浆vWF和IL-6的水平变化,对急性胰腺炎的早期诊断、病情判断和预后评估具有重要的应用价值。更多还原

【Abstract】 Objective:To investigate the changes and clinical significance of serum vWF and IL-6 in acute pancreatitis(AP).Methods:The serum levels of vWF and IL-6 in 24 cases of SAP,44 cases of MAP and 15 normal controls were determined by ELISA.Results:The vWF and IL-6 in the 24patients with SAP was significantly higher than that in 44 patients with MAP,and the 15 healthy volunteers(P<0.05),The sensitivity,specificity,correctly classified were 96.7%,86.7%,91.6% for vWF,and 60%,90%,75% for IL-6 in assessing the severity of pancreatitis.Conclusion: The determination of serum levels of vWF and IL-6 may be valuable for early diagnosis,judgment of severity and prognosis of acute pancreatitis.更多还原