【摘要】 目的:研究联合玉屏风颗粒治疗变应性鼻炎(Allergic rhinitis,AR)的疗效及对AR患者外周血白介素-4(Interleukin,IL-4)和γ-干扰素(Interferon,IFN-γ)的影响。方法:选择我院耳鼻喉科门诊2010年4月-2013年4月AR患者58例,随机分为治疗组与研究组,研究组在治疗组常规使用抗组胺药、抗白三烯药、鼻用或口服糖皮质激素治疗基础上加用玉屏风颗粒。同时选择健康体检者29例为对照组进行对照研究。治疗前及治疗后1个月、3个月、6个月测定外周血IL-4和IFN-γ的浓度,并观察临床症状及体征。结果:治疗组与研究组在治疗前及治疗期间体征评分比较无明显差异(P>0.05),IL-4和IFN-γ水平比较无明显差异(P>0.05)、治疗期间症状评分及疗效两组比较有差异(P<0.05)。停药后3个月两组在症状及体征评分、疗效、IL-4和IFN-γ的水平均有差异(P<0.05)。结论:联合玉屏风颗粒治疗AR可提高疗效,对AR患者的免疫状态有恢复作用且作用长久。更多还原

【Abstract】 Objective:To investigate the curative effect of unite Yupingfeng in AR patients and effect on peripheral blood IL-4 and IFN-γin AR patients.Methods:58AR patients were chosen in outpatients service of Otorhinolaryngology from April 2010 to April 2013.58AR patients were divided into treatment group and research group in random.Treatment group were treated with drug of antihistamine,antileukotriene,intranasal or oral corticosteroids,Research group were treated with Yupingfeng particle in addition.29 Healthy controls were chosen.Peripheral blood concentration of IL-4 and IFN-γwere measured before treatment and one month ,three month s,six month s after treatment.Clinical symptoms and physical signs were observed.Results:Grade of physical signs weren’t different before treatment period and in treatment period between treatment group and research group(P>0.05).Peripheral blood serum concentration of IL-4,IFN-γwere so.Grade of clinical symptoms and curative effect were different in treatment period between treatment group and research group(P<0.05).Grade of clinical symptoms and grate of physical signs and serum concentration of IL-4,IFN-γwere different three month after dug withdrawal.Conclusion:Treatment of unite Yu ping feng can improve efficacy in AR patients.It can improve immune state for long time in AR patients.更多还原