【摘要】 目的观察艾灸对类风湿关节炎模型大鼠关节肿胀度和滑膜细胞凋亡的影响。方法将80只雄性Wistar大鼠随机分为正常组、模型组、艾灸组、艾油组,每组20只。除正常组外,其余3组大鼠建立类风湿关节炎模型。造模成功后,正常组和模型组不予治疗;艾灸组予艾条悬灸;艾油组予艾叶精油涂抹。采用TUNEL法观察艾灸对类风湿关节炎模型大鼠滑膜细胞凋亡的影响以及大鼠关节肿胀度的变化。结果模型组大鼠关节肿胀度及滑膜细胞凋亡与正常组大鼠比较有统计学意义(P<0.01)。经治疗后,艾灸组、艾油组大鼠关节肿胀度和滑膜细胞凋亡指数较模型组大鼠均有所改善,其中,艾灸组大鼠与模型组大鼠比较关节肿胀度和滑膜细胞凋亡指数改善明显(P<0.01),同时艾灸组也优于艾油组。结论这些结果表明,艾灸疗法能够减轻大鼠关节肿胀度,并诱导滑膜细胞凋亡,对类风湿关节炎有很好的治疗作用。更多还原

【Abstract】 Objective Observation on moxibustion on apoptosis of rat synovial cells of rheumatoid arthritis effects,and moxibustion heat stimulating effect on their efficacy. Methods 80 male Wistar rats were randomly assigned to groups,model groups, and moxibustion set correctly,HIV-oil groups,each group of 20. Apart from the normal group,and the remaining 3 Group established rheumatoid arthritis rats model. Modeled after the success of group and model groups are not treated properly. Moxa moxibustion group suspended moxibustion;oil group to Folium artemisiae argyi essential oil from Artemisia argyi with smudge. Using TUNEL method moxibustion on apoptosis of rat synovial cells of rheumatoid arthritis effects. Results Synovial apoptosis in model groups compared statistically with the normal group(P<0. 01). After treatment,moxibustion group,art-oil group synovial apoptosis index of model groups is increased,where the moxibustion group compared with the model groups synovial apoptosis index increased significantly(P <0. 01),while oil group than HIV. HIV-oil group compared with the model group there are also significant differences(P <0. 05). Conclusion Moxibustion therapy can induce apoptosis of synovial cells,has a good therapeutic effect on rheumatoid arthritis,while prompting moxibustion heat stimuli might be the main reason for the effect.更多还原