【摘要】 目的检测可手术根治直肠腺癌患者外周血治疗前后免疫指标的变化及临床意义。方法采用流式细胞仪,对68例直肠腺癌患者手术前、手术后、按期完成6程化疗后的直肠腺癌患者及40例对照组外周血T细胞亚群、NK细胞及B细胞进行检测。结果手术前直肠腺癌组CD8、NK细胞表达明显高于正常对照组;手术后CD4、CD4/CD8、B细胞的表达较手术前明显降低,CD8的表达明显升高;六程化疗后,各项免疫指标较手术后无明显改变。结论大肠腺癌患者存在细胞免疫功能失衡;手术对机体的免疫系统造成进一步抑制;化疗并未进一步降低患者的免疫水平。更多还原

【Abstract】 Objective To test the changes of immunoindicators before and after treatment in peripheral blood in patients with adenocarcinoma of rectum.Methods By using flow cytometry,68 patients in test group were tested for peripheral blood T cell subsets,NK cells and B cells before and after surgery,and after 6-cycles chemothrapy;and 40 in control group were tested too.Results Before surgery,the expression of CD8 and NK cell in test group was higher than that of control group,the difference was significant(P <0.01,P <0.05).After surgery,the expression of CD4,CD4/CD8 and B cells were significantly lower than before the surgery(P<0.01,P<0.01,P<0.05),and CD8 expres-sion was significantly higher(P<0.01).Compared to after surgery,after 6-cycles chemotherapy there were no significant changes in all the immunoindicators.Conclusion There’s dysfunction of cellular immne system in patients with adenocarcinoma of rectum;surgery can suppress the immune system further;but chemotherapy don’t suppress the immune system.更多还原