【摘要】 目的:探讨中国人群男性2型糖尿病患者中β3肾上腺素受体基因Trp64Arg多态性与高尿酸血症的相关性。方法:196名高尿酸血症的2型糖尿病患者和196名正常尿酸水平的2型糖尿病患者进行基因分型。检测体重指数、腰臀比、收缩压、舒张压、血尿酸、肌酐、尿素氮、甘油三酯、低密度脂蛋白胆固醇脂、高密度脂蛋白胆固醇脂、空腹血糖和餐后血糖的水平。结果:高尿酸血症组中,携带不同β3肾上腺素受体Trp64Arg基因型的2型糖尿病患者其尿酸水平有统计学差异,且呈基因剂量效应[CC组(599.53±113.70)vsCT组(529.78±81.10)vs TT组(507.33±74.27),P<0.01]。在该研究中,Trp64Arg TC+CC基因型患者的血尿酸水平亦显著高于TT基因型组[(557.95±99.91)vs(503.47±69.40)μmol/L,P<0.01]。结论:β3肾上腺素受体基因Trp64Arg多态性与2型糖尿病合并高尿酸血症的具有相关性。更多还原

【Abstract】 AIM:To investigate the association of β 3-adrenergic receptor gene Trp64Arg polymorphism with hyperuricemia in a Chinese male type 2diabetes mellitus patients population.METHODS:196hyperuricemic and 196normouricemic male subjects were genotyped in this study.Body mass index(BMI),waist to hip ratio(WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP),serum uric acid,urea nitrogen,creatinine,triglyceride,total cholesterol,low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),fasting plasma glucose(FPG),postprandial plasma glucose(PPG) were detected.RESULTS:We found patients with different Trp64Arg genotype showed significant differences in average uric acid concentrations(599.53±113.70 vs 529.78±81.10 vs 507.33±74.27,P<0.01) among CC,CT and TT genotype and there were significantly higher average uric acid concentrations in Trp64Arg TC+CC genotype individuals(557.95±99.91 vs 503.47±69.40 μ mol/L,P <0.01) than those TT genotype subjects in the hyperuricemic group.CONCLUSION:Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population with type 2diabetes mellitus.更多还原