相关自身免疫性抗体对类风湿关节炎早期诊断的意义

【摘要】 目的同时检测抗环瓜氨酸肽抗体(CCP-Ab)、抗角蛋白抗体(AKA-Ab)、类风湿因子(RF),进一步证实AKA、RF、CCP在类风湿关节炎(RA)患者中的敏感性、特异性和联合检测的意义,探讨早期诊断价值,为临床应用提供依据。方法采用ELISA检测CCP,免疫间接荧光法检测AKA,散射免疫比浊法检测RF。结果 CCP-Ab、AKA-Ab和RF的敏感性和特异性分别为56.99%,96.34%;43.01%,95.1%;58.06%,56.09%。CCP-Ab与AKA-Ab在不同RF含量的阳性率无明显差异,CCP-Ab与AKA-Ab两种方法的检测结果显著相关。结论在对RA早期诊断时,将两种抗体结合起来更有助于对RA早期患者的诊断。更多还原

【Abstract】 Objective We simultaneously detected CCP-Ab,AKA-Ab and RF to confirm their sensitivity,specificity and significance in rheumatoid arthritis(RA) patients,to provide clinical application in early diagnosis.Methods We used ELISA to detect CCP-Ab,immune indirect fluorescence assay for detection of AKA-Ab,scattering immunoturbidimetry for detection of RF.Results Sensitivity and specificity of CCP-Ab,AKA-Ab and RF were 56.99%,96.34%;43.01%,95.1% and 58.06%,56.09%,respectively.Percentage of CCP-Ab and AKA-Ab positive patients in different content of RF positive range was not significantly different.However,results of CCP-Ab and AKA-Ab were highly correlated.Conclusion In the early diagnosis of RA,combination of CCP-Ab and AKA-Ab will be more helpful for clinical patients.更多还原