【摘要】 目的研究分析系统性红斑狼疮疾病的活动指数(SLEDAI)对临床治疗方案的选择和评估价值。方法对每一例SLE患者入院前10d内和经激素和免疫抑制剂治疗2年后活动性进行评价。结果 SLEDAI评分≤9分,纯激素治疗即可取得预期的疗效,如加用环磷酰胺(CTX)冲击治疗将会导致治疗过度;SLEDAI评分10-19分,激素加用CTX为合理的治疗方案,单用激素或给予强化治疗可导致治疗不足或治疗过度;SLEDAI评分≥20分,应给予强化治疗,不然将因治疗不足而导致病情恶化。结论 SLEDAI是评价SLE活动性的较好指标,对临床治疗有较好的指导作用,提示对不同器官及系统受累的患者宜选择不同的治疗方案。更多还原

【Abstract】 Objective To study the relationship between SLEDAI and the clinical treatment.Methods Evaluated the activity of SLE patients to the hospital first 10 days and the hormone and immune inhibitor treatment 2 years later.Results SLEDAI≤9 scores,hormone therapy alone can achieve a satisfactory effect,add cyclophosphamide(CTX) would lead to excessive;SLEDAI 10-19 scores,the hormone+CTX was a reasonable treatment,conventional hormone therapy or to strengthen treatment can lead to inadequate or excessive treatment;SLEDAI≥20 scores,and should intensive treatment,otherwise would to be disease progression because of lack of treatment.Conclusion SLEDAI is a better evaluation SLE activity index,and has a good guidance the better clinical guidance for clinical treatment.And to different organs and systems involved,should choose a different treatments.更多还原