【摘要】 目的:基于灰色关联法评价半夏主要成分与镇咳祛痰效应之间的关系,为半夏质量控制的指标选择提供依据。方法:测定生半夏及其炮制品中3种主要成分(生物碱、多糖、有机酸)的含量,运用小鼠镇咳、祛痰药理模型评价半夏不同炮制品的药效,采用灰色关联法将两者数据相关联,评价半夏镇咳祛痰的成分与效应之间的关系。结果:与半夏镇咳祛痰作用关联的成分关联度大小排序依次为:生物碱>多糖>有机酸。结论:半夏中总生物碱与镇咳祛痰作用的相关性最大,初步确认可以生物碱为指标建立半夏药材的质量控制标准。更多还原

【Abstract】 Objective: To study ingredients-effect relationship of Pinelliae Rhizoma by the Grey incidence degree method,and provide the basis for the indicators of its quality control.Methods: Gray Model was sated up by quantitating the three main ingredients( alkaloids,polysaccharides,and organic acids) and using the antitussive and expectorant pharmacological model to evaluate the effects of Pinelliae Rhizoma and its processed products.Results: The size sort of Grey incidence degree associated with antitussive and expectorant ingredients: alkaloids > organic acids > polysaccharides.Conclusion: As to antitussive and expectorant effect,alkaloids were the most effective ingredient, which could be recognized as indicator for Pinelliae Rhizoma quality control.更多还原