【摘要】 目的分析临床不同类型的烟雾病患者血清成纤维细胞生长因子(b-FGF)水平。方法应用酶联免疫吸附双抗体夹心法(ELISA)检测42例烟雾病患者及40例健康对照者的血清b-FGF水平。结果烟雾病组和对照组血清b-FGF水平差异有统计学意义(P<0.05)。出血型与缺血型烟雾病患者血清b-FGF水平差异有统计学意义(P<0.05),不同Suzuki分级烟雾病患者间差异无统计学意义(P>0.05)。结论烟雾病患者血清b-FGF明显升高,出血型更为显著,提示b-FGF在烟雾病患者新生血管形成机制中可能具有重要作用。更多还原

【Abstract】 【Objective】To study serum b-FGF level of different subtypes of Moyamoya diseases.【Methods】Serum b-FGF level of 42 Moyamoya disease patients and 40 healthy contrasts were analyzed by ELISA.【Resluts】There was significant difference of serum b-FGF between Moyamoya patients and healthy contrast. There was significant difference of serum b-FGF between hemorrhagic Moyamoya patients and ischemic Moyamoya patients. There was no significant difference of serum b-FGF between Moyamoya patients of different Suzuki grading.【Conclusion】Serum b-FGF of Moyamoya disease patients increases significantly, especially in hemorrhagic Moyamoya patients. b-FGF may play important role in the angiogenetic pathology of Moyamoya disease.更多还原