【摘要】 目的探讨C反应蛋白(CRP)在鉴别诊断系统性红斑狼疮(SLE)合并发热中的意义。方法将63例SLE伴发热的患者分为感染组(21例)和非感染组(42例),比较两组CRP水平,分析各组CRP水平与狼疮指标的关系,比较各组不同疾病活动度间CRP水平的差异。结果感染组CRP水平明显高于非感染组(P<0.01),两组CRP水平均与ESR、抗ds-DNA、ANA、尿24小时蛋白定量、淋巴细胞计数及C3无明显关系(P>0.05),各组不同疾病活动度间CRP水平无明显差异(P>0.05)。结论 CRP水平在大部分合并感染的SLE患者中有所升高,对于鉴别诊断狼疮活动与合并感染有一定价值。更多还原

【Abstract】 Objective To explore the clinical significance of C-reactive protein(CRP) in the differentiation of systematic lupus erythematosus complicated with fever.Methods 63 patients with SLE complicated with fever were divided into infection group(21 cases) and non-infection group(42 cases).The relation between CRP level and SLE indexes was analyzed,and the CRP levels of different disease activity were compared.Results The CRP level of infection group was significantly higher than that of non-infection group(P <0.01),with no obvious relation between CRP level and ESR,anti-ds-DNA,ANA,24 h urinary protein,lymphocyte count,C3 in both groups(P >0.05).The difference of CRP levels between patients with different disease activity was not statistically significant(P >0.05).Conclusions CRP level increases in most SLE patients complicated with infection,and it can help to distinguish infection from SLE disease activity.更多还原