【摘要】 目的分析药物性肝损害的病因、临床特点及预后,并评价治疗效果,以提高对药物性肝损害的认识,促进临床合理用药。方法回顾性分析本院2005～2011年间225例药物性肝损害住院患者的基本情况、用药史及临床特点,探讨其发生的可能机制。结果引起药物性肝损害前4位药物分别是抗肿瘤化疗药(35.1%),中草药(19.2%),抗感染药(10.3%),心血管药(10.3%)等,主要临床表现为腹胀、腹痛、纳差、黄疸。肝损害以肝细胞损伤型最为常见。结论引起药物性肝损害的药物种类繁多,临床表现无特异性,因此临床用药要严格把握用药指征,进而做到预防药物性肝损害的发生。更多还原

【Abstract】 Objective To analyze the etiology,clinical characteristics and prognosis of drug hepatic damage,and to evaluate the efficiency of the treatment,in order to improve the understanding of the drug hepatic damage,and so as to promote the clinical rational drug application.Methods The basic situation,the medical history and clinical characteristics of 225 hospitalized patients in 2005-2011 with hepatic damage were retrospectively analyzed,and the possible mechanism was discussed.Results The top 4 drugs that cause drug hepatic damage were antitumor drugs(35.1%),Chinese herbal medicine(19.2%),anti-infective(10.3%) drugs,cardiovascular drugs(10.3%).The main clinical manifestations were as follow: abdominal distension,abdominal pain,anorexia,jaundice.Liver cell damage was the most common type of liver damage.Conclusion There are many kinds of drug that can cause hepatic damage,and there were no specific clinical manifestations.Therefore the clinical application of drugs should strictly be accordance with its indication,to prevent the occurrence of drug hepatic damage.更多还原