Aim To explore the association between cutaneous adverse drug reactions(cADR) and HLA genetic polymorphisms in patients with drug eruption,in order to provide basis for guarding and treating drug eruptions.Methods Forty-eight patients with drug-induced cADR were enrolled to detect HLA-B*1502,HLA-A*0206,HLA-A*3101,HLA-A*1101,HLA-B*5901,HLA-Cw*0704,HLA-Cw*0801,HLA-DRB1*1202 alleles by polymerase chain reaction with sequence specific primers(PCR-SSP).The changes of HLA-B*1502 mRNA level were detected by relati...
药疹为药物超敏反应的特殊类型之一,又称为皮肤药物不良反应(cutaneous adverse drug reac-tions,cADRs),临床上主要分为重症药疹和非重症药疹两类。非重症药疹症状轻微,多在撤药后1~2周内逐渐消退。重症药疹包括Stevens-Johnson综合征(Stevens-Johnson syndrome,SJS)及中毒性