【摘要】 目的探讨2型糖尿病患者血清正五聚蛋白3(PTX3)、超敏C反应蛋白(hs-CRP)及谷氨酰转肽酶(GGT)的检测价值。方法将80例2型糖尿病患者按照不同的尿白蛋白排泄率(UAER)分为正常蛋白尿组(UAER<30 mg/24 h)和微量蛋白尿组(UAER 30~300 mg/24 h),每组40例;另选30例健康志愿者作为对照组。分别检测3组受试者血清PTX3、hs-CRP及GGT水平。结果正常蛋白尿组PTX3及微量蛋白尿组PTX3、hs-CRP和GGT水平均显著高于对照组;微量蛋白尿组PTX3、hs-CRP和GGT水平均显著高于正常蛋白尿组,且血清PTX3、hs-CRP和GGT水平均与UAER呈正相关。结论联合检测PTX3、hs-CRP及GGT水平对糖尿病肾病患者的早期诊断具有重要价值。更多还原

【Abstract】 Objective To investigate the detection value of serum pentraxinA1.3(PTX3),hypersensitive CA1.reactive protein(hsA1.CRP) and gammaA1.glutamyl transpeptidase(GGT) in patients with type 2 diabetes mellitus(T2MD).Methods According to different urinary albumin excretion rates(UAER),80 patients with T2MD were divided into normal albuminuria group(UAER<30 mg/24 h) and microalbuminuria group(UAER 30~300 mg/24 h),40 cases in each group,and 30 healthy people were selected as control group.The levels of serum PTX3,hsA1.CRP and GGT in 3 groups were detected respectively.Results Both levels of PTX3 in normal albuminuria group as well as PTX3,hsA1.CRP and GGT in microalbuminuria group were higher than those in the control group notably.The levels of PTX3,hsA1.CRP and GGT in microalbuminuria group were all distinctly higher than those in normal albuminuria group,and the levels of serum PTX3,hsA1.CRP and GGT were positively associated with UAER.Conclusion Joint detection of serum PTX3,hsA1.CRP and GGT has great values in the early diagnosis of patients with diabetic nephropathy.更多还原