【摘要】 目的观察脱氢表雄酮(DHEA)对卵巢储备功能低下患者卵巢功能及不孕症的治疗效果。方法选择本院收治的诱发排卵失败且卵巢指标证明为卵巢储备功能下降的患者28例,口服DHEA 3个月后再次尝试诱发排卵治疗。比较患者口服DHEA前后卵巢储备指标的变化,观察不孕症的临床结局。结果患者月经周期第3天卵泡刺激素(FSH)、FSH/黄体生成素(LH)、雌二醇(E2)明显下降,窦卵泡计数(AFC)明显上升,显示患者的卵巢功能得到显著改善。患者经3个周期治疗,排卵率达78.3%,累计临床妊娠率达46.4%,流产率为15.4%,其余11例患者均足月产下1活胎,无畸形婴儿出生。结论 DHEA可有效改善卵巢功能及助孕结局。更多还原

【Abstract】 Objective To observe therapeutic effects of dehydroepian drosterone(DHEA) on the ovarian function and infertility of patients with decline in ovarian reserve.Methods Twenty-eight patients with failure in inducing ovulation and decline in ovarian reserve confirmed by ovarian indexes were selected,and tried to receive induced ovulation again 3 months after oral administration of DHEA.The changes of ovarian reserve indexes before and after oral administration of DHEA were compared,and clinical outcomes of infertility were observed.Results On the 3rd day of menstrual cycle, follicle-stimulating hormone(FSH),FSH/ lutenizing hormone(LH) and estradiol (E2) obviously decreased,while antral follicle count(AFC) significantly increased,suggesting that the ovarian function of patients markedly improved.After 3 cycles of treatment,the ovulation rate came to 78.3%,accumulated clinical pregnancy rate to 46.4% and abortion rate to 15.4%.All other 11 cases delivered 1 live birth at full-term time,with no oafs.Conclusion DHEA can effectively ameliorate the ovarian function and reproductive outcomes.更多还原