【摘要】 目的建立反相高效液相色谱（RP-HPLC）法测定人体血浆中伊洛哌酮的含量。方法色谱柱为美国Diamonsil（?）C₁₈反相柱（250mm×4.6mm,5μm）,流动相为乙腈-甲醇-缓冲液（40:55:5,V/V/V）,流速为1.0 mL·min^-1,柱温35℃,检测波长280 nm。结果伊洛哌酮血浆质量浓度在0.021².688 mg·L^-1范围内线性关系良好（r=0.998 9）,平均相对回收率为98.21%,平均日间精密度为6.02%。结论本法快速、简便、准确,适于伊洛哌酮药动学研究和临床监测。更多还原

【Abstract】 AIM To establish a RP-HPLC method for content determination of iloperidone in human plasma.METHODS A Diamonsil C₁₈ column（250 mm×4.6 mm,5 μm） was used with mobile phase of acetonitrile-methanol-buffer（40:55:5,V/V/V）.Flow rate was 1.0 mL·min^-1,column temperature was 35℃.UV detection wavelength was 280 nm.RESULTS Within a mass concentration range of 0.021-2.688 mg·L^-1,standard curve of iloperidone had a good linearity（r = 0.998 9）.The average relative recovery was 98.21%,and the average daytime precision was 6.02%.CONCLUSION This method is rapid,convenient and accurate.It can be used for the pharmacokinetics study and clinical monitor of iloperidone.更多还原