【摘要】 目的分析乳果糖口服溶液、聚乙二醇4000散和麻仁软胶囊治疗高龄老人功能性便秘的成本-效果。方法将258例高龄老人功能性便秘的患者随机分为三组,分别给予乳果糖口服溶液,每次15～30 mL,早餐后1次口服(乳果糖组);聚乙二醇4000散,每次20 g,早餐前冲服(聚乙二醇组)和麻仁软胶囊,每次1.2 g,早餐后1次口服(麻仁组),2周和4周后评价药物的疗效,4周后计算治疗成本,进行药物经济学评价。结果治疗2周和4周后乳果糖组总有效率明显高于聚乙二醇组和麻仁组,差异有显著意义(P<0.05、P<0.01)。乳果糖口服溶液、聚乙二醇4000散和麻仁软胶囊治疗高龄老人功能性便秘的成本分别为570.6、482.0和340.6元;成本-效果比分别为5.8、5.5和4.7。结论乳果糖口服溶液治疗高龄老年人功能性便秘效果最好,但成本-效果比略高于其他两药。在评价药物治疗成本时,必须考虑药物的疗效、疗程以及安全性。更多还原

【Abstract】 AIM To analyze the cost-effectiveness of oral lactulose solution,macrogol 4000 powder and maren capsules in treatment of chronic functional constipation in aged patients.METHODS Two hundred and fifty-eight aged patients with chronic functional constipation were randomly divided into three groups,with 86 patients in each group.The three groups were respectively given oral lactulose solution(lactulose group)15-30 mL after breakfast once a day,macrogol 4000 powder(macrogol group)20 g boiled in water before breakfast once a day,and maren capsules(maren group)1.2 g after breakfast once a day for 4 weeks.Then the treatment costs was counted and the cost-effectiveness was evaluated.RESULTS The total efficiency of the lactulose group was higher than that of the macrogol group and maren group(P < 0.05,P < 0.01).The costs of the three groups were 570.6,482.0 and 340.6 yuan respectively,and the cost-effectiveness of them were 5.8,5.5 and 4.7 respectively.CONCLUSION Compared with macrogol 4000 powder and maren capsules,oral lactulose solution would probably have the best effect in the treatment of functional constipation.However,its cost-effectiveness is slightly higher than the other two drugs.In evaluation of the drug therapy costs,the efficacy,course and safety of the treatment must be considered.更多还原