【摘要】 目的:了解原发性肝癌患者的临床特点。方法:分析415例原发性肝癌患者的临床资料,包括年龄、性别、病因(肝炎病毒感染史、肝硬化病史、饮酒史)、甲胎蛋白、肝功能、凝血功能、影像学检查结果。结果:415例原发性肝癌患者男368例(88.7%),女47例(11.3%),男女之比为5.49∶1;41～60岁239例(57.59%)(P<0.05);患有肝硬化297例(77.83%),其中乙型肝炎肝硬化71.33%,HBV感染占91.08%(P<0.05),HBV DNA定量大于5×105IU/L的患者300例(85.47%);甲胎蛋白升高(>50 mg/L)245例(59.04%);有乙型肝炎家族史占26.51%,肝癌家族史占3.61%;肝癌破裂出血5.78%。结论:原发性肝癌以中年、男性、HBV感染、肝硬化和家族史为高危因素,对于HBV感染有乙型肝炎或肝癌家族史的中年男性,需要加强随访和肝癌监测。更多还原

【Abstract】 Objective:To investigate the clinical characteristics of patients with primary hepatic carcinoma.Methods:Clinical data including age,gender,etiology(hepatitis virus infection,cirrhosis,alcoholism),alpha-fetoprotein(AFP),liver function,coagulation function and imaging examination of the 415 patients were analyzed retrospectively.Results:Male patients accounted for 88.7%(368/415) of all cases,and femal for 11.3%(47/415),repectively(5.49:1).Middle-aged patients(41-60 years old) accounted for 57.59%(239/415)(P<0.05).Hepatic cirrhosis patients accounted for 77.83%,and those related with hepatitis B accounted for 71.33%.HBV infection accounted for 91.08%(P<0.05).In 85.47% of cases,HBVDNA quantification were over 5×105 IU/L.AFP level arised in 245 case.26.51% of all patients presented with family history of hepatitis B,and 3.61% cases with family history of hepatic carcinoma,5.78% cases with hepatic carcinoma rupture hemorrhage.Conclusion:Risk factors of primary hepatic carcinoma included middle-aged,male,HBV infection,hepatic cirrhosis,family history of hepatitis B and hepatic carcinoma.Hence middle-aged men with HBV infection,family history of hepatitis B or hepatic carcinoma,should be under close observation on tumor formation.更多还原