【摘要】 目的探讨尿毒清颗粒对维持性血液透析患者微炎症状态的改善作用。方法将维持性血液透析半年以上的患者240例随机分为透析对照组、中药组(尿毒清颗粒口服)、西药组(维生素E口服),每组80例,另设健康对照组30例。分别于治疗前及治疗1、3、6个月后检测各组超敏C反应蛋白、白细胞介素-6、同型半胱氨酸水平。结果透析患者治疗前炎症因子水平均显著高于健康对照组。治疗3个月后,中药组各炎症因子水平明显下降,治疗6个月后下降更明显(P<0.01),与透析对照组比较差异有统计学意义(P<0.01)。西药组治疗前后炎症因子水平无明显变化。结论尿毒清颗粒可以明显改善维持性血液透析患者的微炎症状态,与维生素E相比疗效显著。更多还原

【Abstract】 Objective To investigate the effect of Niaoduqing Particles on the microinflammatory state in patients with maintenance hemodialysis.Methods Totally 240 patients with hemodialysis for more than 6 months were randomly divided into conventional hemodialysis group,Chinese medicine group(treated with Niaoduqing Particles) and western medicine group(treated with Vitamin E),80 cases in each group,with 30 healthy people as control group.The levels of hs-CRP,IL-6 and HCY were detected before and after1,3,6 months of treatment.Results Before treatment,the levels of inflammatory factors in hemodialysis patients were higher than control group.And after 3 months of treatment,the levels of hs-CRP,IL-6 and HCY of Chinese medicine group were decreased.And after 6 months of treatment,the levels of inflammatory factors were decreased obviously compared with pretherapy(P <0.01),and the difference with the conventional hemodialysis group was significant(P <0.01).Compared with pretherapy,the changes of inflammatory factors of western medicine group were statistically insignificant.Conclusion Niaoduqing Particles can significantly improve the microinflammatory state in maintenance hemodialysis patients,and the effect is superior to Vitamin E.更多还原