【摘要】 目的:探讨抗Sa和CCP抗体对类风湿关节炎诊断意义的比较及其联合检测的意义。方法:采用ELISA法检测抗Sa抗体和抗CCP抗体。结果:抗Sa抗体和抗CCP抗体对RA特异性和敏感性分别为97.26%和60.67%、98.63%和92.13%,抗CCP抗体较抗Sa抗体敏感性高(P<0.05),两种抗体联合检测对RA诊断的特异性高达100%,敏感性为60.67%。抗Sa抗体阳性组中疼痛肿胀关节数大于阴性组(P<0.05),抗CCP阳性组中疼痛肿胀关节数及ANA阳性率大于阴性组(P<0.05)。结论抗CCP抗体敏感性高于抗Sa抗体,二者联合检测可以进一步提高RA诊断特异性。更多还原

【Abstract】 Objective To compare the anti-Sa antibody,anti-CCP antibody and analyze and detect the diagnostic significane of the anti-Sa antibody,anti-CCP antibody in patient with RA.Methods anti-Sa antibody,anti-CCP antibody were deteceted by ELISA.Results The specificitiy and sensitivity of anti-Sa antibody,anti-CCP antibody were 97.26%and 60.67%,98.63%and 92.13%.The sensitivity of anti-CCP antibody were higher than anti-Sa antibody. The RA patients with anti-Sa were statistically different from the patients without this antibody in counts of joints with pain and swelling;The RA patients with anti-CCP were statistically different from the patients without this antibody in counts of joints with pain and swelling,and in male of antinuclear antibody.Conclusion The sensitivity of anti-CCP antibody were higher than anti-Sa antibody.更多还原