【摘要】 目的探讨心脏舒张功能不全(DD)患者生活质量(QoL)状况及相关影响因素。方法依据超声心电图结果将患者分为DD伴充盈压升高组(DD+)和DD不伴充盈压升高组(DD-)及舒张功能正常组(N)。采用SF-36健康调查量表进行QoL测评。多元回归分析评价相关影响因素。结果纳入328例患者,DD+组QoL量表各项评估普遍较低(均为P<0.001)。在生理功能项目评价上,DD+组评分[(66±26)分]较DD-组[(75±24)分]和N组[(80±23)分]均显著降低(均为P<0.001)。多元回归分析显示,仅舒张早期二尖瓣血流速度与舒张早期二尖瓣环运动速度的比值(E/e)与生理功能受损显著相关(均为P=0.046)。结论 DD患者QoL评分普遍下降,以生理健康总分下降为主,常见的一些临床变量用于解释QoL下降意义有限。更多还原

【Abstract】 Objective To evaluate the quality of life(QoL) of patients with diastolic dysfunction(DD) and the risk factors of QoL.Methods Totally 328 patients were included and were classified into three groups: normal diastolic function group(group N),DD with(group DD+) or without(group DD-) elevated filling pressure according to the results of echocardiography.The SF-36 was used for QoL evaluation.Results SF-36 score was significantly lower in group DD+(66±26) than in group DD-(75±24) or in group N(80±23)(both P<0.001).Multivariate regression analysis showed that only E/e′ is associated with SF-36-PF.Conclusions The SF-36 score is decreased in DD patients.更多还原