【摘要】 目的探讨生长抑素(somatostatin,SS)对术后早期炎性肠梗阻(early postoperative inflammatory ileus,EPII)的治疗效果。方法回顾分析我院收治的43例结肠癌EPII患者的临床资料,按照是否应用SS及SS的剂量分为对照组(15例)、6 mg SS治疗组(14例)和9 mg SS治疗组(14例)。对照组除不使用SS外,其他与治疗组一致,6 mg SS治疗组及9 mg SS治疗组每日静脉持续输入SS 6 mg及9 mg。比较不同组患者临床症状改善、EPII治愈时间及治疗费用。结果与对照组相比,SS治疗组的患者腹痛、腹胀持续时间明显缩短,肛门排气时间亦明显小于对照组。6 mg SS治疗组平均胃液引流量(753.90±180.00)ml/d,显著少于对照组(967.40±243.00)ml/d,差异有统计学意义(P<0.05);6 mg SS治疗组EPII治愈时间(8.75±2.55)天,显著短于对照组(13.40±3.65)天(P<0.01);两组治疗费用无显著性差异。9 mg SS治疗组与6 mg SS治疗组比较,腹痛、腹胀持续、肛门排气时间改善,差异无统计学意义,每日平均胃液引流量相近,EPII治疗时间和治疗费用亦无统计学差异。结论生长抑素能抑制消化液分泌,减轻肠壁水肿,促进肠蠕动,对治疗结肠癌EPII有明显作用。更多还原

【Abstract】 Objective To investigate the treatment effect of somatostatin(SS)on early postoperative inflammatory ileus(EPII) after operation for colorectal cancer. Methods The clinical data of 43 EPII patients after operation for colorectal cancer were analyzed retrospectively. All the patients were divided into control group(routine therapy without SS, n=15), 6 mg SS group(6 mg / d, n=14) and 9 mg SS group(9mg / d,n=14). The clinical symptoms and treatment duration and cost of EPII were compared among three groups. Results Compared with the control group,the durations of abdominal pain and abdominal distention, restoration of anal exhaust were significantly decreased in the SS treatment groups. The mean volume of gastric decompression was(753.90 ±180.00)ml / d, treatment duration of EPII(8.75 ±2.55)d in the 6 mg SS treatment group,significantly less than(967.40±243.00)ml / d and shorter than(13.40±3.65)d in the control group. There was no significant difference in treatment cost between the control group and 6mg SS group. No differences in the durations of abdominal pain and abdominal distention, restoration of anal exhaust, mean volume of gastric decompression, treatment duration and cost between the 6 mg and 9 mg SS groups. Conclusion SS can inhibit the secretion of digestive juice, reduce the intestinal wall edema,promote intestinal peristalsis and has positive effect on EPII after operation for colorectal cancer.更多还原