【摘要】 目的探讨不同人口学因素对直肠癌根治术后患者生存质量的影响。方法对2002年8月至2011年2月间在中山大学附属第一医院胃肠外科行直肠癌根治手术后随访半年以上的患者,采用欧洲癌症研究治疗组织QLQ-C30与CR38量表进行术后生存质量的横断面调查,按不同人口学指标进行分组,对各组生存质量得分比较分析。结果共收到269份有效量表。青年比中老年直肠癌患者在社会-心理学相关领域如情绪功能(P=0.021)和未来期望(P=0.044)方面,承受更大损害,而老年患者则主要是在生理相关领域如躯体功能(P=0.039)、性功能(P<0.001)和性感受(P<0.001)方面受损更严重。女性患者比男性患者生存质量得分低主要集中在性功能(P=0.022)、性感受(P=0.036)及症状领域如疲倦(P=0.043)、疼痛(P=0.002)、失眠(P=0.018)及胃肠症状(P=0.029)。教育程度低以及无工作的患者生存质量更差。结论不同社会人口学特征的直肠癌患者术后生存质量受损领域和程度各不相同,术后随访、康复治疗以及社会支持需有针对性地进行。更多还原

【Abstract】 Objective To investigate the impacts of sociodemographic characteristics on healthrelated quality of life(HRQoL) in disease-free survivors after radical surgery for rectal cancer in a Chinese mainland population. Methods A cross-sectional survey of 438 patients who underwent curative surgery for rectal cancer from August 2002 to February 2011 using the European Organization for Research and Treatment of Cancer QLQ-C30 and CR-38 questionnaires. The patients without postoperative major comorbidities and recurrence were followed-up for a minimum of 6 months, and asked to complete the two questionnaires. The impacts of different sociodemographic characteristics on HRQoL were compared by univariate analysis. Results Two-hundred and sixty-nine effective responses were received.Psychological-related HRQoL such as emotional function(P=0.021) and future perspective(P=0.044)in young patients were significantly poorer than those in old ones, and physiological-related HRQoL such as physical function(P=0.039), sexual function(P<0.001) and sexual feeling(P<0.001) were significantly poorer in old patients than those in young ones. The female patients got poorer physiologic function and symptom HRQoL such as sexual function(P =0.022), sexual feeling(P =0.036), fatigue(P=0.043), pain(P=0.002) and insomnia(P=0.018) than the male patients. Low education and not working were associated with worse HRQoL. Conclusions HRQoL will be impaired after curative surgery for rectal cancer. HRQoL aspects and degrees are different according to many sociodemographic factors in Chinese mainland patients. Follow-up, rehabilitation and social support should be carried on pertinently.更多还原