【摘要】 目的:比较依诺肝素联合替罗非班,对比普通肝素联合替罗非班在治疗急性心肌梗死过程中的有效性与安全性。方法:连续入选我院急性心肌梗死患者256例,随机分为依诺肝素组129例,普通肝素组127例,两组都联合应用替罗非班、阿司匹林及氯吡格雷等治疗。对比两组患者30 d内总死亡、心源性死亡、再发心肌梗死及支架内血栓等临床事件;并比较两组患者72 h内出血并发症及血小板变化情况。结果:30 d内总死亡、心源性死亡、再发心肌梗死及支架内血栓等临床事件,依诺肝素组较普通肝素组减少,但差异无统计学意义(P>0.05);72 h内出血并发症,依诺肝素组较普通肝素组稍高,但差异亦无统计学意义(P>0.05);治疗72h前后血小板数量下降程度,依诺肝素组较普通肝素组低(P<0.05)。结论:相对于普通肝素,依诺肝素联合替罗非班治疗急性心肌梗死是安全有效的。更多还原

【Abstract】 Objective:To compare efficacy and safety of Enoxaparin combined Tirofinban with Unfractionated heparin combined Tirofinban in the process of treating acute myocardial infarction.Methods: We enrolled on 256 consecutive patients admitted with AMI in our hospital.Patients were randomly divided into 129 of Enoxaparin group and 127of Unfractionated heparin group,both of them using Tirofiban,Aspirin and Clopidogrel treatment.To investigate the incidence in total deaths,cardiac death,recurrent myocardial infarction,stent thrombosis and other clinical events within 30d,and incidence in bleeding and platelet count in 72 hours.Results: Enoxaparin group had lower incidence of total deaths,cardiac death,recurrent myocardial infarction,stent thrombosis and other clinical events within 30d compared to Unfractionated heparin group,but no statistically significant difference(P>0.05);Enoxaparin group had higher incidence in bleeding within 72 hours,but no statistically significant difference(P>0.05).There was statistically significant difference(P<0.05) in platelet count drop before and after treating with Enoxaparin group compared to Unfractionated heparin in 72 hours.Conclusion:Instead of unfractionated heparin,Enoxaparin is feasible for AMI patients combined Tirofiban.更多还原