【摘要】 目的探讨有机磷中毒患者在急救护理过程中多项细胞因子变化及急救护理体会。方法采用酶联免疫吸附试验(ELISA)双抗体夹心法对58例有机磷中毒(AOPP)与58例健康体检者(对照组)测定血清白细胞介素-6(IL-6)、IL-10、肿瘤坏死因子α(TNF-α)的水平变化。结果有机磷农药中毒患者入院第1天、第3天、第5天的IL-6、IL-10、TNF-α水平均明显高于对照组(p<0.05),从第3天或第5天开始下降。58例患者中18例出现呼吸衰竭,其中呼吸衰竭患者的血浆IL-6、IL-10、TNF-α水平高于非呼吸衰竭患者(p<0.05)。结论有机磷中毒可导致体内细胞因子失调,细胞因子参与了全身炎症反应综合征的发生和发展,及时采取有效救治和护理,是抢救成功和减少并发症的关键。更多还原

【Abstract】 Objective To investigate the changes of serum factors and nursing for organophosphorus poisoning patients.Methods Double antibody sandwich-enzyme-linked immunosorbent assay(DAS-ELISA) was used for the determination of serum interleukin-6(IL-6),IL-10,tumor necrosis factor α(TNF-α) level changes.Results The level of IL-6,IL-10,TNF-α of the patients with organophosphorus poisoning was significantly higher than that of the control group respectively on the day admitted to hospital,the third day,the fifth day,(p < 0.05),and began to decline from the third day or the fifth day.Conclusion Organophosphorus poisoning can lead to cytokine imbalance,cytokines involved in the occurrence and development of systemic inflammatory response syndrome of patients with organophosphorus poisoning,nursing care is the key to successful treatment.更多还原