【摘要】 目的探讨低分子肝素联合母体水化治疗妊娠晚期羊水过少的临床疗效及安全性。方法将87例羊水过少妊娠晚期孕妇,随机分为两组,其中治疗组44例,对照组43例。对照组采用母体水化疗法:静脉滴注5%葡萄糖1 000 ml/d,饮水2 000 ml/d。治疗组在静脉补液的基础上加低分子肝素50 mg/d,饮水2 000 ml/d。对治疗前后两组的羊水指数(AFI)变化、剖宫产率、新生儿体重、新生儿阿氏评分及产后出血量等数据进行统计分析。结果治疗后治疗组的羊水指数提升明显高于对照组(p<0.05),剖宫产率较对照组明显降低(p<0.05),新生儿体重较对照组略高但无统计学意义(p>0.05),两组新生儿阿氏评分无差异,出血量和产后出血发生率差异均无显著性(p>0.05)。结论低分子肝素联合母体水化疗法可明显提高妊娠晚期羊水过少的治疗效果,增加羊水指数,降低剖宫产率,不增加产后出血量和产后出血的发生率。这种方法用于基层医疗机构具有简便安全不增加患者费用的优势。更多还原

【Abstract】 Objective To study the effect and safety of low molecular heparin combined with maternal hydration treatment on oligohydramnios in late pregnancy.Methods 87 cases of oligohydramnios in late pregnancy were randomly divided into two groups,control group 43 cases that were treated by 5% glucose 1 000 ml intravenously and drinking water 2 000 ml,and treat group 44 cases that were treated by 5% glucose 1 000 ml with low molecular heparin 50 mg / d intravenously and drinking water 2 000 ml.The differences of amniotic fluid index(AFI),cesarean section rate,neonatal body weight,and neonatal apgar scoring,postpartum blood loss data between two groups were statistical analyzed after treatment.Results The amniotic fluid index in treatment group was significantly higher(p < 0.05),cesarean section rate was significantly lower compared to control group(p < 0.05);birth weight of two groups has no statistical significance(p > 0.05);the neonatal apgar scoring,the bleeding volume and incidence rate of postpartum hemorrhage between two groups has no significant difference(p > 0.05).Conclusion Low molecular heparin combined with maternal hydration therapy can obviously improve the therapeutic effect of oligohydramnios in late pregnancies,which showed that AFI increase,the incidence rate of cesarean delivery decrease,and postpartum blood loss and accidence rate of postpartum hemorrhage does not increase evidently.This method used for basic medical institution has the advantages of simple,safety and low cost.更多还原