【摘要】 目的探讨血清白细胞介素1(interleukin-1,IL-1)在妊娠期糖尿病(gestational diabetes mellitus,GDM)的临床应用价值。方法采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测48例妊娠糖尿病患者即GDM组、36例正常糖耐量(normal glucose tolerance,NGT)妊娠妇女即NGT组血清中IL-1水平,统计数据进行相关性分析。结果 (1)GDM组空腹血糖(fasting blood glucose,FBG)、稳态模型胰岛素抵抗指数(Homeostasis model as-sessment-insulin resistance,HOMA-IR)、IL-1水平均明显高于NGT组,两组差异有统计学意义(P﹤0.01)。(2)IL-1与HOMA-IR具有极显著正相关,相关系数为0.810,P﹤0.01。结论 IL-1与GDM具有相关性,可能均参与GDM的发生与发展,IL-1作为炎性因子可能会促进GDM的发生、发展。更多还原

【Abstract】 OBJECTIVE To discuss the clinical application value of serum interleukin 1 (IL-1) in the gestational diabetes (GDM). METHODS By ELISA test (ELISA) detection, 48 gestational diabetes patients were as GDM group, 36 normal glucose tolerance pregnant women as NGT group. The serum IL-1 level were analyzed with the correlation analysis. RESULTS (1) FBG, HOMA-IR, IL-1 level in GDM group were significantly higher than that in NGT group (P﹤0.01). (2) IL-1, HOMAIR had a very significantly positive correlation. Correlation coefficient was 0.810, P﹤0.01. CONCLUSION IL-1 has a relevance with GDM, which participates in the occurrence and development of the GDM, IL-1 as inflammatory factor may promote the occurrence and development of GDM.更多还原