【摘要】 目的分析产ESBLs大肠埃希菌的临床分离和药敏情况,并与不产酶的大肠埃希菌的情况进行比较。方法回顾性分析198株产ESBLs大肠埃希菌和287株不产ESBLs大肠埃希菌的耐药情况,采用χ2检验分析耐药株和敏感株的来源差异和对常用抗菌药物的敏感性差异。结果药敏实验证实产ESBLs大肠埃希菌和不产ESBLs大肠埃希菌除对亚胺培南、美洛培南和阿米卡星的敏感性差异无统计学意义外(P﹥0.05),对其他抗菌药物的敏感性差异都有统计学意义(P﹤0.05),产ESBLs大肠埃希菌对这些抗菌药物的耐药率相对于不产ESBLs大肠埃希菌都有不同程度的提高。结论由于产ESBLs大肠埃希菌耐药机制的多样性和存在多重耐药情况,在临床确诊产ESBLs大肠埃希菌株感染时应根据药敏结果合理使用抗菌药物,同时应该珍惜使用对产ESBLs大肠埃希菌和不产ESBLs大肠埃希菌治疗无显著差异的碳青霉烯类以及阿米卡星等抗菌药物。更多还原

【Abstract】 OBJECTIVE To analyze drug sensitivity of ESBL-producing Escherichia coli and compare with non-ESBL-producing Escherichia coli.METHODS We got 198 ESBL-producing Escherichia coli and 287 non-ESBL-producing Escherichia coli.The results of ESBL-producing Escherichia coli and non-ESBL-producing Escherichia coli were analysed by χ2 test.RESULTS There were no significant differences in drug sensitivity of ESBL-producing Escherichia coli and Non-ESBL-producing Escherichia coli to imipenem,meropenem and amikacin(P﹥0.05).Drug sensitive test discovered that there were significant differences in drug sensitivity of ESBL-producing Escherichia coli and non-ESBL-producing Escherichia coli to other antibiotics(P﹥0.05),and drug sensitivity of ESBL-producing Escherichia coli was higher than non-ESBL-producing Escherichia coli.CONCLUSION We should use drug to treat patients in time and reasonably when the patient is diagnosed as infection by ESBL-producing Escherichia coli.The antibiotics of carbopenems and amikacin should be used carefully.更多还原