【摘要】 背景:牙髓干细胞是来源于牙髓组织中的一种成体干细胞,该种细胞具有高度增殖、自我更新的能力和多向分化潜能。通过对牙髓干细胞的深入研究,有助于人类为组织工程研究提供可能的细胞来源,进而指导临床相关治疗与预防。目的:就牙髓干细胞的研究现状及其在组织工程中的应用作一综述。方法:应用计算机检索CNKI和Pubmed数据库中2000年1月至2012年5月关于牙髓干细胞的文章,在标题和摘要中以"牙髓干细胞,诱导,培养,分化"或"dental pulp stem cells,culture,induced,differentiation"为检索词进行检索。选择文章内容与牙髓干细胞有关者,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到205篇文献,根据纳入标准选择关于牙周局部缓释剂的44篇文献进行综述。结果与结论:相比较其他成体干细胞,牙髓干细胞的研究尚面临许多问题。但随着科学技术的日益进步,随着这些问题的深入探讨和逐步解决,牙髓干细胞的研究将日趋完善。牙髓干细胞有望成为牙组织工程、骨组织工程和神经组织工程的种子细胞,在牙髓再生、牙体的修复等方面有着广阔的应用前景。更多还原

【Abstract】 BACKGROUND: Dental pulp stem cells is a kind of adult stem cells derived from dental pulp and possess high proliferation rate, self-renewal capability and multi-differentiation capability. Dental pulp stem cells are possible cell sources for tissue engineering and are therefore used for prevention and treatment of tooth-related diseases in the clinic. OBJECTIVE: To summarize the current progress of dental pulp stem cells and their application in tissue engineering. METHODS: A computer-based online retrieval of CNKI and PubMed databases (2000-01/2012-05) was performed to search papers regarding dental pulp stem cells by inputting "dental pulp stem cells, culture, induced, differentiation" in the title and abstract search boxes. The papers published recently or in high impact journals were selected. A total of 205 papers were initially retrieved. Forty-four papers regarding sustained-release antimicrobials were suitable for final analysis. RESULTS AND CONCLUSION: Compared to other adult stem cells, there are many unsolved problems regarding dental pulp stem cells. With a gradual improvement in the scientific technology, these problems will be investigated and gradually solved. Dental pulp stem cells are promising seed cells for bone tissue engineering, dental tissue engineering and nerve tissue engineering. Dental pulp stem cells hold great promise in dental pulp regeneration and dental restoration.更多还原