【摘要】 背景:人工制得的羟基磷灰石具有较强的比表面,极易发生团聚。目的:解决羟基磷灰石团聚问题,使其分散性更好。方法:以硝酸钙和磷酸二氢氨为原料,采用溶液共沉淀法制备纳米羟基磷灰石,分别应用聚乙二醇(2%,4%,5%,6%,8%)、聚乙烯醇(2%,4%,5%,6%,8%)、硬脂酸(2%,4%,5%,6%,8%)对其进行改性。结果与结论:X射线衍射分析显示获得了纯度较高的纳米羟基磷灰石。在表面包覆改性纳米羟基磷灰石时,表面改性剂种类、活性剂浓度等都对其粒径大小产生影响。综合考察羟基磷灰石合成及改性过程中的影响因素主要得出以下结论:通过对羟基磷灰石改性,羟基磷灰石对聚乙二醇、聚乙烯醇、硬脂酸具有一定的选择性,聚乙二醇对羟基磷灰石改性最好,且浓度为5%时羟基磷灰石分散性最好。更多还原

【Abstract】 BACKGROUND: The prepared hydroxyapatite is likely agglomerated due to its specific surface area. OBJECTIVE: To investigate the agglomeration problem of hydroxyapatite and to improve the dispersity of hydroxyapatite. METHODS: The nano-hydroxyapatite was prepared using solution coprecipitation method from calciumnitrate and ammonium di-hydrogen phosphate and further modified by combination of polyethylene glycol (2%, 4%, 5%, 6%, 8%), polyvinyl alcohol (2%, 4%, 5%, 6%, 8%), and stearic acid (2%, 4%, 5%, 6%, 8%). RESULTS AND CONCLUSION: Nano-hydroxyapatite was successfully obtained through X-ray diffraction analysis. The type of surface modifying agent and active agent concentration could affect the particle size of the hydroxyapatite when cladded by them. After considering the influential factors in processes of synthesis and modification, the following conclusions can be determined: Polyethylene glycol is the best modifying agent for hydroxyapatite in all three modifying agents which involve polyethylene glycol, polyvinyl alcohol and stearic acid. Furthermore, the dispersity of the hydroxyapatite is excellent after modification by 5% polyethylene glycol.更多还原