【摘要】 背景:普遍认为雌激素和成骨特异性转录因子(runt-related transcription factor2,Runx2)是骨骼形成和维持的重要调控因子。目的:分析总结目前有关成骨细胞中雌激素与Runx2相互作用的研究进展,综述在成骨细胞中雌激素与Runx2相互作用的分子机制。方法:以"雌激素"、"成骨特异性转录因子"、"成骨细胞"、"Runx-2"、"Estrogen"为检索词,检索PubMed数据库、中国生物医学文献数据库、维普期刊全文数据库、万方数据库有关文章。排除重复性研究及无关研究。计算机初步检索得到62篇文献,经过进一步研读分析,保留22篇进行总结。结果与结论:研究发现,雌激素和Runx2在成骨细胞中并不是孤立的发挥作用,而是通过多种方式相互协同,共同发挥对成骨细胞的调控,作用于骨代谢过程。雌激素与Runx2之间存在的复杂作用机制,除E2/ER与Runx2直接作用外还涉及到许多信号系统,如转化生长因子β信号通路,Wnt/β-连锁蛋白信号通路,Fas/FasL信号通路和核因子κB信号通路等。更多还原

【Abstract】 BACKGROUND:It is widely believed that estrogen and runt-related transcription factor 2 (Runx2) are important regulatory factors in the formation and maintenance of bone. OBJECTIVE:To summarize the recent research progresses and to elaborate the molecular mechanism of interaction between estrogen and Runx2 in osteoblasts. METHODS:"Estrogen", "runt-related transcription factor 2 (Runx2)" and "osteoblast" were used as search terms in Chinese and English to retrieve PubMed, China Biology Medicine disc, VIP journal full-text database, WanFang database. Repeatability studies and irrelevant researches were excluded. Totally 62 literatures were obtained with preliminary retrieval and 22 were reserved after further study and analysis. RESULTS AND CONCLUSION:A mass of scientific researchers have found that estrogen and Runx2 do not function independently in osteoblasts but interact with each other through multiple patterns to co-regulate osteoblasts. There exist a complex mechanism of interaction between estrogen and Runx2. Various pathways are involved besides the direct action between estrogen/estrogen receptor and Runx2, such as transforming growth factor-β pathway, Wnt/β-catenin pathway, Fas/Fas ligand pathway and nuclear factor kappa B pathway.更多还原