【摘要】 目的了解男男性行为人群(MSM)艾滋病病毒(HIV)感染者及病人中,合并人乳头状瘤病毒(HPV)感染及其亚型分布状况。方法采用杂交捕获法,分别对MSM人群的HIV感染者及病人(观察组)和男性尖锐湿疣患者(对照组)进行HPV分型检测。结果在观察组91例患者中,合并HPV阳性检出率为73.63%(67/91),共检出15个HPV亚型,其中高危亚型11个(16、18、31、33、45、52、56、59、66、68、73型),低危亚型4个(6、11、42、43型)。单一亚型感染占31.34%(21/67),多重亚型感染占68.66%(46/67)。高危亚型感染占44.78%(30/67),低危亚型感染占55.22%(37/67)。观察组病例的多重亚型HPV感染率(χ2=30.6474,P<0.000 1)和高危亚型HPV感染率(χ2=22.3210,P<0.000 1)都高于对照组,差异有统计学意义。结论在MSM人群中,HIV合并HPV感染呈较高流行状态,HIV感染者罹患肛门生殖器肿瘤的风险增加,提示加强HIV感染者HPV感染的防治有重要意义。更多还原

【Abstract】 Objective To explore the status of HPV infection and the distribution of HPV subtypes among HIV positive MSM.Methods The detections of HPV-subtypes targeting HIV positive MSM(trial group) and the male patients with condyloma acuminatum(control group) were performed with hybrid capture approach.Results Of the 91 patients in the trial group,73.63%(67/91) were HPV positive,and 15 subtypes of HPV including 11 high-risk subtypes(16,18,31,33,45,52,56,59,66,68 and 73) and 4 low-risk subtypes(6,11,42 and 43) were identified.Single HPV-subtype infections accounted for 31.34%(21/67),multiple HPV-subtype infections accounted for 68.66%(46/67),high-risk HPV-subtype infections accounted for 44.8%(30/67) and low-risk HPV-subtype infections accounted for 55.2%(37/67).Compared with the control group,the multiple HPV-subtype infections and high-risk HPV-subtype infections in the trial group were significantly higher.Conclusion A high prevalence of HPV and HIV co-infections were found among MSM population,and the HIV infected people were at a higher risk for the anus and genital tumors.The study indicated that it is important to strengthen prevention and control focusing on HPV infection among MSM.更多还原