【Objective】 The changing of the frequencies of 4 nucleotides as the generations changed using Tamura model,which is a more complicated nucleotide substitution model,was studied to obtain the entropy properties of DNA sequences.【Method】 Based on Shannon entropy theory,the theoretical demonstration was proved by the Lagrange Multiplier Method,and Mathematica was used to simulate the changing patterns of 4 nucleotides.【Result】 If the mutation in the DNA sequence occurs in Tamura model,the frequencies of nucleo...
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